• Eisenhardt M, Leixner S, Luján R, Spanagel R, Bilbao A. (2015) Glutamate Receptors within the Mesolimbic Dopamine System mediate alcohol relapse behaviour. J Neurosci 35(47):15523-38.

    https://www.ncbi.nlm.nih.gov/pubmed/26609150


    Luján R, Aguado C. (2015) Localization and Targeting of GIRK channels in Mammalian Central Neurons. Int Rev Neurobiol 123:161-200.

    https://www.ncbi.nlm.nih.gov/pubmed/26422985


    Marron Fernandez de Velasco E, Hearing M, Xia Z, Victoria NC, Luján R, Wickman K. (2015) Sex differences in GABABR-GIRK signaling in layer 5/6 pyramidal neurons of the mouse prelimbic cortexNeuropharmacology 95:353-60.

    http://www.ncbi.nlm.nih.gov/pubmed/25843643


    Lopes JP, Morató X, Souza C, Pinhal C, Machado NJ, Canas PM, Silva HB, Stagljar I, Gandía J, Fernández-Dueñas V, Luján R, Cunha RA, Ciruela F. (2015) The role of parkinson’s disease-associated receptor GPR37 in the hippocampus: functional interplay with the adenosinergic systemJ Neurochem 134(1):135-46.

    http://www.ncbi.nlm.nih.gov/pubmed/25824528


    Orlandi C, Xie K, Masuho I, Fajardo-Serrano A, Luján R, Martemyanov KA. (2015) Orphan Receptor GPR158 Is an Allosteric Modulator of RGS7 Catalytic Activity with an Essential Role in Dictating Its Expression and Localization in the BrainJ Biol Chem 290(22):13622-39.

    http://www.ncbi.nlm.nih.gov/pubmed/25792749


    Murcia-Belmonte V, Esteban PF, Martínez-Hernández J, Gruart A, Luján R, Delgado-García JM, de Castro F. (2015) Anosmin-1 over-expression regulates oligodendrocyte precursor cell proliferation, migration and myelin sheath thickness. Brain Struct Funct 221(3):1365-85.

    http://www.ncbi.nlm.nih.gov/pubmed/25662897


    Martinello K, Huang Z, Luján R, Tran B, Watanabe M, Cooper EC, Brown DA, Shah MM. (2015) Cholinergic afferent stimulation induces axonal function plasticity in adult hippocampal granule cells. Neuron 85(2):346-63.

    http://www.ncbi.nlm.nih.gov/pubmed/25578363


    Weber T, Vogt MA, Gartside SE, Berger SM, Luján R, Lau T, Herrmann E, Sprengel R, Bartsch D, Gass P. (2015) Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activityNeuropsychopharmacology 40(6):1471-84.

    http://www.ncbi.nlm.nih.gov/pubmed/25547714


    Fernández-Dueñas V, Taura JJ, Cottet M, Gómez-Soler M, López-Cano M, Ledent C, Watanabe M, Trinquet E, Pin JP, Luján R, Durroux T, Ciruela F. (2015) Untangling dopamine-adenosine receptor-receptor assembly in experimental parkinsonism in ratsDis Model Mech 8(1):57-63.

    http://www.ncbi.nlm.nih.gov/pubmed/25398851


    Gómez-Gonzalo M, Navarrete M, Perea G, Covelo A, Martín-Fernández M, Shigemoto R, Luján R, Araque A. (2015) Endocannabinoids induce Long-Term Potentiation of Transmitter Release by Stimulation of Gliotransmission. Cereb Cortex 25(10):3699-712.

    https://www.ncbi.nlm.nih.gov/pubmed/25260706


    Hepp R, Hay YA, Aguado C, Lujan R, Dauphinot L, Potier MC, Nomura S, Poirel O, El Mestikawy S, Lambolez B, Tricoire L. (2015) Glutamate receptors of the delta family are widely expressed in the adult brain. Brain Struct Funct 220(5):2797-815.

    https://www.ncbi.nlm.nih.gov/pubmed/25001082

  • Ballesteros-Merino C, Martínez-Hernández J, Aguado C, Watanabe M, Adelman JP, Luján R. (2014) Localization of SK2 channels relative to excitatory synaptic sites in the mouse developing Purkinje cellsFront Neuroanat 8:154.

    http://www.ncbi.nlm.nih.gov/pubmed/25565979


    Devesa I, Ferrándiz-Huertas C, Mathivanan S, Wolf C, Luján R, Changeux JP, Ferrer-Montiel A. (2014) αCGRP is essential for algesic exocytotic movilization of TRPV1 channels in peptidergic nociceptorsProc Natl Acad Sci U S A 111(51):18345-50.

    http://www.ncbi.nlm.nih.gov/pubmed/25489075


    Matsukawa H, Akiyoshi-Nishimura S, Zhang Q, Luján R, Yamaguchi K, Goto H, Yaguchi K, Hashikawa T, Sano C, Shigemoto R, Nakashiba T, Itohara S. (2014) Netrin-G/NGL Complexes Encode Functional Synaptic Diversification. Journal of Neuroscience 34:15779-15792.

    http://www.ncbi.nlm.nih.gov/pubmed/25411505


    García-Negredo G, Soto D, Llorente J, Morató X, Galenkamp KMO, Gómez-Soler M, Fernández-Dueñas V, Watanabe M, Adelman JP, Shigemoto R, Fukazawa Y, Luján R, Ciruela F (2014) Co-assembly and couplintg of SK2 and mGlu5 receptors. Journal of Neuroscience 34:14793-14802.

    http://www.ncbi.nlm.nih.gov/pubmed/25355231


    Ito S, Magalska A, Alcaraz-Iborra M, López-Atalaya JP, Rovira V, Contreras-Moreira B, Lipinski M, Olivares R, Martínez-Hernández J, Ruszczycki B, Luján R, Geijo-Barrientos E, Wilczynski G, Barco A (2014) Loss of neuronal 3D chromatin organization causes transcriptional and behavioural deficits related to serotonergic dysfunction. Nature Communications 5:4455.

    http://www.ncbi.nlm.nih.gov/pubmed/25034090


    Dragicevic E, Poetschke C, Duda J, Schlaudraff F, Lammel S, Schiemann J, Fauler M, Hetzel A, Watanabe M, Luján R, Malenka RC, Striessnig J, Liss B (2014) Cav1.3 channels control D2-autoreceptor responses via NCS-1 in substantia nigra dopamine neurons. Brain 137(Pt 8):2287-302.

    http://www.ncbi.nlm.nih.gov/pubmed/24934288


    Ostrovskaya O, Xie K, Masuho I, Fajardo-Serrano A, Luján R, Wickman K, Martemyanov KA (2014) RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. Elife 3:e02053. doi: 10.7554/eLife.02053

    http://www.ncbi.nlm.nih.gov/pubmed/24755289


    Zhang L, Hernández VS, Estrada FS, Luján R (2014) Hippocampal CA field neurogenesis after pilocarpine insult: The hippocampal fissure as a neurogenic niche. Journal of Chemical Neuroanatomy 56:45-57.

    http://www.ncbi.nlm.nih.gov/pubmed/24607693


    Ballesteros-Merino C, Watanabe M, Shigemoto R, Fukazawa Y, Adelman JP, Luján R (2014) Differential subcellular localization of SK3 channels in the hippocampus. European Journal of Neuroscience 39(6):883-92.

    http://www.ncbi.nlm.nih.gov/pubmed/24405447


    Luján R, Marron Fernández de Velasco E, Aguado C, Wickman K (2014) New Insights into the therapeutic potential of GIRK channels. Trends in Neuroscience 37(1):20-9.

    http://www.ncbi.nlm.nih.gov/pubmed/24268819

  • Fajardo-Serrano A, Wydeven N, Young D, Watanabe M, Shigemoto R, Martemyanov KA, Wickman K, Luján R (2013) Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus 23(12):1231-45.

    http://www.ncbi.nlm.nih.gov/pubmed/23804514


    Marco S, Giralt A, Petrovic MM, Pouladi MA, Martínez-Turrillas R, Martínez-Hernández J, Kaltenbach LS, Torres-Peraza J, Graham RK, Watanabe M, Luján R, Nakanishi N, Lipton SA, Lo DC, Hayden MR, Alberch J, Wesseling JF, Pérez-Otaño I (2013) Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington’s disease models. Nature Medicine 19(8):1030-8

    http://www.ncbi.nlm.nih.gov/pubmed/23852340


    Kawahara A, Kurauchi S, Fukata Y, Martínez-Hernández J, Yagihashi T, Itadani Y, Sho R, Kajiyama T, Shinzato N, Narusuye K, Fukata M, Luján R, Shigemoto R, Ito I (2013) Neuronal major histocompatibility complex class I molecules are implicated in the generation of asymmetries in hippocampal circuitry. Journal of Physiology 591(Pt 19):4777-91

    http://www.ncbi.nlm.nih.gov/pubmed/23878366


    Ferrero JJ, Alvarez AM, Ramírez-Franco J, Godino MC, Bartolomé-Martín D, Aguado C, Torres M, Luján R, Ciruela F, Sánchez-Prieto J (2013) β-Adrenergic Receptors Activate Exchange Protein Directly Activated by cAMP (Epac), Translocate Munc13-1, and Enhance the Rab3A-RIM1α Interaction to Potentiate Glutamate Release at Cerebrocortical Nerve Terminals. Journal of Biological Chemistry 288(43):31370-85

    http://www.ncbi.nlm.nih.gov/pubmed/24036110


    Hearing M, Kotecki L, Marron Fernandez de Velasco E, Fajardo-Serrano A, Chung HJ, Luján R, Wickman K (2013) Repeated Cocaine Weakens GABAB-Girk Signaling in Layer 5/6 Pyramidal Neurons in the Prelimbic Cortex. Neuron 80(1):159-70

    http://www.ncbi.nlm.nih.gov/pubmed/24094109


    Soden ME, Jones GJ, Sanford CA, Chung AS, Güler AD, Chavkin C, Luján R, Zweifel LS (2013) Disruption of Dopamine Neuron Activity Pattern Regulation through Selective Expression of a Human KCNN3 Mutation. Neuron 80(4):997-1009

    http://www.ncbi.nlm.nih.gov/pubmed/24206670

     

  • Díaz-Vera J, Camacho M, Machado JD, Domínguez N, Montesinos MS, Hernández-Fernaud JR, Luján R, Borges R (2012) Chromogranins A and B are key proteins in amine accumulation, but the catecholamine secretory pathway is conserved without them. FASEB Journal 26(1):430-8.

    http://www.ncbi.nlm.nih.gov/pubmed/21990378


    Pérez-Carrión MD, Pérez-Martínez FC, Merino S, Sánchez-Verdú P, Martínez-Hernández J, Luján R, Ceña V (2012) Dendrimer-mediated siRNA delivery knocks down Beclin 1 and potentiates NMDA-mediated toxicity in rat cortical neurons. Journal of Neurochemistry 120(2):259-68.

    http://www.ncbi.nlm.nih.gov/pubmed/22035151


    Xie K, Ge S, Collins VE, Haynes CL, Renner KJ, Meisel RL, Luján R, Martemyanov KA (2012) Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems. Psychopharmacology (Berl) 219(3):823-34.

    http://www.ncbi.nlm.nih.gov/pubmed/21766168


    Padgett CL, Lalive AL, Tan KR, Terunuma M, Moss SJ, Martínez-Hernández J, Watanabe M, Luján R, Lüscher C, Slesinger PA (2012) Methamphetamine-evoked depression of GABAB receptor signalling in GABA neurons of the VTA. Neuron 73(5):978-89.

    http://www.ncbi.nlm.nih.gov/pubmed/22405207


    Martínez-Hernández J, Ballesteros-Merino C, Fernandez-Alacid L, Nicolau JC, Luján R (2012) Polarized localization of the voltage-gated sodium channel Nav1.2 in cerebellar granule cells. Cerebellum 12(1):16-26.

    http://www.ncbi.nlm.nih.gov/pubmed/22528969


    Rozas JL, Gómez-Sánchez L, Mirchesk J, Linares-Clemente P, Nieto-González JL, Vázquez ME, Luján R, Fernández-Chacón R (2012) Motorneurons require cysteine string protein- to maintain the readily releasable vesicular pool and synaptic vesicle recycling. Neuron 74(1):151-65.

    http://www.ncbi.nlm.nih.gov/pubmed/22500637


    Ferrandiz-Huertas C, Gil-Minguez M, Luján R (2012) Regional expression and subcellular localization of the β subunits of voltage-gated calcium channels in the developing brain. Journal of Neurochemistry 122(6):1095-107.

    http://www.ncbi.nlm.nih.gov/pubmed/22737983


    Deignan J, Luján R, Bond C, Riegel A, Watanabe M, Williams JT, Maylie J, Adelman JP (2012) SK2 and SK3 expression differentially affect firing frequency and precision in dopamine neurons. Neuroscience 217:67-76.

    http://www.ncbi.nlm.nih.gov/pubmed/22554781


    Huang Z, Luján R, Martinez-Hernandez J, Lewis AS, Chetkovich DM, Shah MM (2012) TRIP8b-independent trafficking and plasticity of adult cortical presynaptic HCN1 channels. Journal of Neuroscience 32(42):14835-48.

    http://www.ncbi.nlm.nih.gov/pubmed/23077068


    Aguado C, Fernández-Alacid L, Cabañero MJ, Yanagawa Y, Schilling K, Watanabe M, Fritschy JM, Luján R (2012) Differential maturation of GIRK2-expressing neurons in the mouse cerebellum. Journal of Chemical Neuroanatomy 47:79-89

    http://www.ncbi.nlm.nih.gov/pubmed/23261870

  • Allen D, Nakayama S, Kuroiwa M, Nakano T, PALMATEER J, Kosaka Y, BALLESTEROS C, WATANABE M, Bond CT, Luján R, Maylie J, Adelman JP, Herson PS (2011) SK2 channels are neuroprotective for ischemia-induced neuronal cell death. J Cereb Blood Flow Metab 31(12):2302-12

    http://www.ncbi.nlm.nih.gov/pubmed/21712833


    Huang Z, Luján R, Kadurin I, Uebele VN, Renger JJ, Dolphin AC, Shah MM (2011) Presynaptic HCN1 channels regulate Cav3.2 activity and neurotransmission at select cortical synapses. Nature Neuroscience 14(4):478-86.

    http://www.ncbi.nlm.nih.gov/pubmed/21358644


    Allen D*, Bond CT*, Luján R*, Ballesteros-Merino C, Lin MT, Wang K, Klett N, Watanabe M, Shigemoto R, Stackman RW Jr, Maylie J, Adelman JP (2011) The SK2-long isoform directs synaptic localization and function of SK2-containing channels. Nature Neuroscience 14(6):744-749.

    http://www.ncbi.nlm.nih.gov/pubmed/21602822


    Arora D, Hearing M, Haluk DM, Mirkovic K, Fajardo-Serrano A, Wessendorf MW, Watanabe M, Luján R, Wickman K (2011) Acute cocaine exposure weakens GABA(B) receptor-dependent G-protein-gated inwardly rectifying K+ signaling in dopamine neurons of the ventral tegmental area. Journal of Neuroscience 31(34):12251-7.

    http://www.ncbi.nlm.nih.gov/pubmed/21865468


    Luján R, Ciruela F (2011) GABAB Receptors-Associated Proteins: Potential Drug Targets In Neurological Disorders? Curr Drug Targets 13(1):129-44.

    http://www.ncbi.nlm.nih.gov/pubmed/22023408


    Ballesteros-Merino C, Lin M, Wu WW, Ferrandiz-Huertas C, Cabañero MJ, Watanabe M, Fukazawa Y, Shigemoto R, Maylie J, Adelman JP, Luján R (2011) Developmental profile of SK2 channel expression and function in CA1 neurons. Hippocampus 22(6):1467-80.

    http://www.ncbi.nlm.nih.gov/pubmed/22072564


    Fernández-Alacid L, Watanabe M, Molnár E, Wickman K, Luján R (2011) Developmental regulation of G protein-gated inwardly-rectifying K+ (GIRK/Kir3) channel subunits in the brain. European Journal of Neuroscience 34(11):1724-36.

    http://www.ncbi.nlm.nih.gov/pubmed/22098295

  • Bauer CS, Rahman W, Tran-van-Minh A, Luján R, Dickenson AH, Dolphin AC (2010) The anti-allodynic alpha(2)delta ligand pregabalin inhibits the trafficking of the calcium channel alpha(2)delta-1 subunit to presynaptic terminals in vivo. Biochem Soc Trans 38(2):525-8.

    http://www.ncbi.nlm.nih.gov/pubmed/20298215


    Luján R (2010) Organisation of potassium channels on the neuronal surface. Journal of Chemical Neuroanatomy 40(1):1-20.

    http://www.ncbi.nlm.nih.gov/pubmed/20338235


    Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B (2010) Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling. Nature 464(7293):1376-80.


    Valor LM, Jancic D, Luján R, Barco A (2010) Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function. Cell Death Differ 17(10):1636-44.

    http://www.ncbi.nlm.nih.gov/pubmed/20393464


    Yu K, Luján R, Marmorstein A, Gabriel S, Hartzell HC (2010) Bestrophin-2 mediates bicarbonate transport by goblet cells in mouse colon. J Clin Invest 120(5):1722-35.

    http://www.ncbi.nlm.nih.gov/pubmed/20407206


    García-Junco-Clemente P, Cantero G, Gómez-Sánchez L, Linares-Clemente P, Martínez-López JA, Luján R, Fernández-Chacón R (2010) Cysteine string protein-alpha prevents activity-dependent degeneration in GABAergic synapses. Journal of Neuroscience 30(21):7377-91.

    http://www.ncbi.nlm.nih.gov/pubmed/20505105


    Arora D, Haluk DM, Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R, Wickman K (2010) Altered neurotransmission in the mesolimbic reward system of Girk mice. Journal of Neurochemistry 114(5):1487-97.

    http://www.ncbi.nlm.nih.gov/pubmed/20557431


    Lin MT*, Luján R*, Watanabe M, Frerking M, Maylie J, Adelman JP (2010) Coupled activity-dependent trafficking of synaptic SK2 channels and AMPA receptors. Journal of Neuroscience 30(35):11726-34.

    http://www.ncbi.nlm.nih.gov/pubmed/20810893


    Ciruela F, Fernández-Dueñas V, Sahlholm K, Fernández-Alacid L, Nicolau JC, Watanabe M, Luján R (2010) Evidence for oligomerization between GABA(B) receptors and GIRK channels containing the GIRK1 and GIRK3 subunits. European Journal of Neuroscience 32(8):1265-77.

    http://www.ncbi.nlm.nih.gov/pubmed/20846323


    Nassirpour R, Bahima L, Lalive AL, Lüscher C, Luján R, Slesinger PA (2010) Morphine- and CaMKII-dependent enhancement of GIRK channel signalling in hippocampal neurons. Journal of Neuroscience 30(40):13419-30.

    http://www.ncbi.nlm.nih.gov/pubmed/20926668


    Brown MT, Bellone C, Mameli M, Labouèbe G, Bocklisch C, Balland B, Dahan L, Luján R, Deisseroth K, Lüscher C (2010) Drug-driven AMPA receptor redistribution mimicked by selective dopamine neuron stimulation. PLoS One 5(12):e15870.

    http://www.ncbi.nlm.nih.gov/pubmed/21209835

  • Bauer C, Nieto-Rostro M, Rahman W, Tran Van Minh A, Ferron L, Douglas L, Kadurin I, Sri Ranjan Y, Fernández-Alacid L, Millar N, Dickenson A, Luján R, Dolphin A (2009) The increased trafficking of the calcium channel subunit 21 to presynaptic terminals in neuropathic pain is inhibited by the ligand pregabalin. Journal of Neuroscience 29(13):4076-4088.

    http://www.ncbi.nlm.nih.gov/pubmed/19339603


    Cabello N, Gandía J, Bertarelli DCG, Watanabe M, Lluís C, Franco R, Ferré S, Luján R, Ciruela F (2009) Metabotropic glutamate type 5, Dopamine D2 AND adenosine a2a receptors form higher-order oligomers in living cells. Journal of Neurochemistry 109(5):1497-507.

    http://www.ncbi.nlm.nih.gov/pubmed/19344374


    Anderson GR, Luján R, and Martemyanov KA (2009) Changes in striatal signalling induce remodeling of RGS complexes containing Gβ5 and R7BP subunits. Molecular and Cellular Biology 29(11):3033-3044.

    http://www.ncbi.nlm.nih.gov/pubmed/19332565


    Vida RL, Valenzuela JI, Luján R, Couve A (2009) Cellular and subcellular localization of Martlin-1 in the brain. BMC Neuroscience 10:37

    http://www.ncbi.nlm.nih.gov/pubmed/19386132


    Longordo F, Kopp C, Mishina M, Luján R, Luthi A (2009) NR2A at CA1 synapses is obligatory for the susceptibility of hippocampal plasticity to sleep loss. Journal of Neuroscience 29(28):9026-41.

    http://www.ncbi.nlm.nih.gov/pubmed/19605640


    Luján R, Maylie J, Adelman JP (2009) New sites of action for GIRK and SK channels. Nature Reviews Neuroscience 10(7):475-80.

    http://www.ncbi.nlm.nih.gov/pubmed/19543219


    Fernández-Alacid L, Aguado C, Ciruela F, Martín R, Colón J, Cabañero MJ, Gassmann M, Watanabe M, Shigemoto R, Wickman K, Bettler B, Sánchez-Prieto J, Luján R (2009) Subcellular compartment-specific molecular diversity of pre- and postsynaptic GABA(B)-activated GIRK channels in Purkinje cells. Journal of Neurochemistry 110:1363-1376.

    http://www.ncbi.nlm.nih.gov/pubmed/19558451


    Astori S, Luján R, Köhr G (2009) GABA release from cerebellar stellate cells is developmentally regulated by presynaptic GABAB receptors in a target-cell-specific manner. European Journal of Neuroscience 30:551-559.

    http://www.ncbi.nlm.nih.gov/pubmed/19674089


    Roberts AC, Díez-García J, Rodriguiz R, López IP, Luján R, Martínez-Turrillas R, Picó E, Henson MA, Bernardo DN, Jarrett TM, Clendeninn DJ, López-Mascaraque L, Feng G, Lo DC, Wesseling JF, Wetsel WC, Philpot BD, Pérez-Otaño I (2009) Down-regulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. Neuron 63(3):342-56.

    http://www.ncbi.nlm.nih.gov/pubmed/19679074


    Canela L, Fernández-Dueñas V, Albergaria C, Watanabe M, Lluís C, Mallol J, Canela EI, Franco R, Luján R, Ciruela F (2009) The association of metabotropic glutamate receptor type 5b with the Neuronal Ca2+-binding protein 2 modulates receptor function. Journal of Neurochemistry 111(2):555-67.

    http://www.ncbi.nlm.nih.gov/pubmed/19694902


    Gomez-Sanchez J, Lopez de Armentia M, Luján R, Kessaris N, Richardson W, Cabedo H (2009) Sustained axon-glial signalling induces Schwann cell hyperproliferation, Remak bundle myelination and tumorigenesis. Journal of Neuroscience 29(36):11304 –11315.

    http://www.ncbi.nlm.nih.gov/pubmed/19741137


    Quiroz C, Luján R, Uchigashima M, Simoes AP, Lerner TN, Borycz J, Kachroo A, Canas PM, Orru M, Schwarzschild MA, Rosin DL, Kreitzer AC, Cunha RA, Watanabe M, Ferré S (2009) Key modulatory role of presynaptic adenosine A2A receptors in cortical neurotransmission to the striatal direct pathway. ScientificWorldJournal 9:1321-44.

    http://www.ncbi.nlm.nih.gov/pubmed/19936569

     

  • Ladera C, del Carmen Godino M, José Cabañero M, Torres M, Watanabe M, Luján R, Sánchez-Prieto J (2008) Pre-synaptic GABA receptors inhibit glutamate release through GIRK channels in rat cerebral cortex. Journal of Neurochemistry 107(6):1506-17.
    http://www.ncbi.nlm.nih.gov/pubmed/19094055


    Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R (2008) Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron 59(3):497-508.

    http://www.ncbi.nlm.nih.gov/pubmed/18701074


    Perry CA, Pravetoni M, Teske JA, Aguado C, Erickson DJ, Medrano JF, Luján R, Kotz CM, Wickman K (2008) Predisposition to late-onset obesity in GIRK4 knockout mice. PNAS 105(23):8148-53.

    http://www.ncbi.nlm.nih.gov/pubmed/18523006


    Cueni L, Canepari M, Luján R, Emmenegger Y, Watanabe M, Bond CT, Franken P, Adelman JP, Lüthi A (2008)T-type Ca2+ channels, SK2 channels and SERCAs gate sleep-related oscillations in thalamic dendrites. Nature Neuroscience 11(6):683-92.

    http://www.ncbi.nlm.nih.gov/pubmed/18488023


    Luján R, de Cabo C, Juiz JM (2008) Inhibitory synaptogenesis in the rat anteroventral cochlear nucleus. Neuroscience 154(1):315-28.

    http://www.ncbi.nlm.nih.gov/pubmed/18434029


    Lin MT, Luján R, Watanabe M, Adelman JP, Maylie J (2008) SK2 channel plasticity contributes to LTP at Schaffer collateral-CA1 synapses. Nature Neuroscience 11(2):170-7.

    http://www.ncbi.nlm.nih.gov/pubmed/18204442


    Rebola N, Lujan R, Cunha RA, Mulle C (2008) Adenosine A2A receptors are essential for long-term potentiation of NMDA-EPSCs at hippocampal mossy fiber synapses. Neuron 57(1):121-34.

    http://www.ncbi.nlm.nih.gov/pubmed/18184569


    Aguado C, Colón J, Ciruela F, Schlaudraff F, Cabañero MJ, Perry C, Watanabe M, Liss B, Wickman K, Luján R (2008) Cell type-specific subunit composition of G protein-gated potassium channels in the cerebellum. Journal of Neurochemistry 105(2):497-511.

    http://www.ncbi.nlm.nih.gov/pubmed/18088366

  • Anderson GR, Lujan R, Semenov A, Pravetoni M, Posokhova EN, Song JH, Uversky V, Chen CK, Wickman K, Martemyanov KA (2007) Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases. Journal of Neuroscience 27(51):14117-27.
    http://www.ncbi.nlm.nih.gov/pubmed/18094251


    Labouèbe G, Lomazzi M, Cruz HG, Creton C, Luján R, Li M, Yanagawa Y, Obata K, Watanabe M, Wickman K, Boyer SB, Slesinger PA, Lüscher C (2007) RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area. Nature Neuroscience 10(12):1559-68.

    http://www.ncbi.nlm.nih.gov/pubmed/17965710


    Ladera C, Godino Mdel C, Martín R, Luján R, Shigemoto R, Ciruela F, Torres M, Sánchez-Prieto J (2007) The coexistence of multiple receptors in a single nerve terminal provides evidence for pre-synaptic integration. Journal of Neurochemistry 103(6):2314-26.

    http://www.ncbi.nlm.nih.gov/pubmed/17944874


    Canela L, Luján R, Lluís C, Burgueño J, Mallol J, Canela EI, Franco R, Ciruela F (2007) The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor. Molecular Cell Neuroscience 36(1):1-12.

    http://www.ncbi.nlm.nih.gov/pubmed/17689978


    Mameli M, Balland B, Luján R, Lüscher C (2007) Rapid synthesis and synaptic insertion of GluR2 for mGluR-LTD in the ventral tegmental area. Science 317(5837):530-3.

    http://www.ncbi.nlm.nih.gov/pubmed/17656725


    Luján R (2007) Subcellular regulation of metabotropic GABA receptors in the developing cerebellum. Cerebellum 6(2):123-9.

    http://www.ncbi.nlm.nih.gov/pubmed/17510912

  • Marker CL, Luján R, Colón J, Wickman K (2006) Distinct populations of spinal cord lamina II interneurons expressing G-protein-gated potassium channels. Journal of Neuroscience 26(47):12251-9.
    http://www.ncbi.nlm.nih.gov/pubmed/17122050


    Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, Kaupmann K, Gassmann M, Oertner TG, Bettler B (2006) Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron 50(4):589-601.

    http://www.ncbi.nlm.nih.gov/pubmed/16701209


    Pérez-Otaño I, Luján R, Tavalin SJ, Plomann M, Modregger J, Liu XB, Jones EG, Heinemann SF, Lo DC, Ehlers MD (2006) Endocytosis and synaptic removal of NR3A-containing NMDA receptors by PACSIN1/syndapin1. Nature Neuroscience 9(5):611-21.

    http://www.ncbi.nlm.nih.gov/pubmed/16617342


    Luján R, Shigemoto R (2006) Localization of metabotropic GABA receptor subunits GABAB1 and GABAB2 relative to synaptic sites in the rat developing cerebellum. European Journal of Neuroscience 23(6):1479-90.

    http://www.ncbi.nlm.nih.gov/pubmed/16553611


    Ciruela F, Casadó V, Rodrigues RJ, Luján R, Burgueño J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortés A, Canela EI, López-Giménez JF, Milligan G, Lluis C, Cunha RA, Ferré S, Franco R (2006) Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. Journal of Neuroscience 26(7):2080-7.

    http://www.ncbi.nlm.nih.gov/pubmed/16481441

  • Koyrakh L, Luján R, Colón J, Karschin C, Kurachi Y, Karschin A, Wickman K (2005) Molecular and cellular diversity of neuronal G-protein-gated potassium channels. Journal of Neuroscience 25(49):11468-78.
    http://www.ncbi.nlm.nih.gov/pubmed/16339040


    Caminos E, Vale C, Lujan R, Martinez-Galan JR, Juiz JM (2005) Developmental regulation and adult maintenance of potassium channel proteins (Kv 1.1 and Kv 1.2) in the cochlear nucleus of the rat. Brain Research 1056(2):118-31.

    http://www.ncbi.nlm.nih.gov/pubmed/16122713


    Luján R, Albasanz JL, Shigemoto R, Juiz JM (2005) Preferential localization of the hyperpolarization-activated cyclic nucleotide-gated cation channel subunit HCN1 in basket cell terminals of the rat cerebellum. European Journal of Neuroscience 21(8):2073-82.

    http://www.ncbi.nlm.nih.gov/pubmed/15869503


    Marker CL, Luján R, Loh HH, Wickman K (2005) Spinal G-protein-gated potassium channels contribute in a dose-dependent manner to the analgesic effect of mu- and delta- but not kappa-opioids. Journal of Neuroscience 25(14):3551-9.

    http://www.ncbi.nlm.nih.gov/pubmed/15814785


    Luján R, Shigemoto R, López-Bendito G (2005) Glutamate and GABA receptor signalling in the developing brain. Neuroscience 130(3):567-80.

    http://www.ncbi.nlm.nih.gov/pubmed/15590141


    Luján R (2005) Receptores metabotrópicos de glutamato: nuevas dianas moleculares en la terapia de enfermedades neurológicas y psiquiátricas. Revista de Neurología 40:43-53.
    http://www.ncbi.nlm.nih.gov/pubmed/15696426

  • López-Bendito G, Shigemoto R, Kulik A, Vida I, Fairén A, Luján R (2004) Distribution of metabotropic GABA receptor subunits GABAB1a/b and GABAB2 in the rat hippocampus during prenatal and postnatal development. Hippocampus 14(7):836-48.
    http://www.ncbi.nlm.nih.gov/pubmed/15382254


    Luján R, Shigemoto R, Kulik A, Juiz JM (2004) Localization of the GABAB receptor 1a/b subunit relative to glutamatergic synapses in the dorsal cochlear nucleus of the rat. Journal of Comparative Neurology 475(1):36-46.

    http://www.ncbi.nlm.nih.gov/pubmed/15176083


    Panzanelli P, López-Bendito G, Luján R, Sassoé-Pognetto M (2004) Localization and developmental expression of GABA(B) receptors in the rat olfactory bulb. Journal of Neurocitology 33(1):87-99.

    http://www.ncbi.nlm.nih.gov/pubmed/15173634


    Kulik A, Nakadate K, Hagiwara A, Fukazawa Y, Luján R, Saito H, Suzuki N, Futatsugi A, Mikoshiba K, Frotscher M, Shigemoto R (2004) Immunocytochemical localization of the alpha 1A subunit of the P/Q-type calcium channel in the rat cerebellum. European Journal of Neuroscience 19(8):2169-78.

    http://www.ncbi.nlm.nih.gov/pubmed/15090043

  • Kulik A, Vida I, Luján R, Haas CA, López-Bendito G, Shigemoto R, Frotscher M (2003) Subcellular localization of metabotropic GABA(B) receptor subunits GABA(B1a/b) and GABA(B2) in the rat hippocampus. Journal of Neuroscience 23(35):11026-35.
    http://www.ncbi.nlm.nih.gov/pubmed/14657159


    Luján R, de Cabo de la Vega C, Dominguez del Toro E, Ballesta JJ, Criado M, Juiz JM (2003) Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat. Journal of Chemical Neuroanatomy 26(3):209-24.

    http://www.ncbi.nlm.nih.gov/pubmed/14615029


    López-Bendito G, Luján R, Shigemoto R, Ganter P, Paulsen O, Molnár Z (2003) Blockade of GABA(B) receptors alters the tangential migration of cortical neurons. Cerebral Cortex 13(9):932-42.

    http://www.ncbi.nlm.nih.gov/pubmed/12902392


    Somogyi P, Dalezios Y, Luján R, Roberts JD, Watanabe M, Shigemoto R (2003) High level of mGluR7 in the presynaptic active zones of select populations of GABAergic terminals innervating interneurons in the rat hippocampus. European Journal of Neuroscience 17(12):2503-20.

    http://www.ncbi.nlm.nih.gov/pubmed/12823458

  • Millan, C, Lujan, R, Shigemoto, R, and Sánchez-Prieto, J (2002) The inhibition of glutamate release by mGluR7 affects both [Ca2+]c and cAMP: evidence for a strong reduction of Ca2+ entry in single nerve terminals. Journal of Biological Chemistry 16:625-38.
    http://www.ncbi.nlm.nih.gov/pubmed/11825890


    López-Bendito, G, Shigemoto, R, Fairén, A and Lujan, R (2002) Differential distribution of Group I metabotropic glutamate receptors during rat cortical development. Cerebral Cortex 12:625-38.

    http://www.ncbi.nlm.nih.gov/pubmed/12003862


    Dalezios Y, Luján R, Shigemoto R, Roberts JD, Somogyi P (2002) Enrichment of mGluR7a in the presynaptic active zones of GABAergic and non-GABAergic terminals on interneurons in the rat somatosensory cortex. Cerebral Cortex 12(9):961-74.
    http://www.ncbi.nlm.nih.gov/pubmed/12183395


    Millán C, Luján R, Shigemoto R, Sánchez-Prieto J (2002) Subtype-specific expression of group III metabotropic glutamate receptors and Ca2+ channels in single nerve terminals. Journal of Biological Chemistry 277(49):47796-803.

    http://www.ncbi.nlm.nih.gov/pubmed/12376542


    López-Bendito G, Shigemoto R, Kulik A, Paulsen O, Fairén A, Luján R (2002) Expression and distribution of metabotropic GABA receptor subtypes GABABR1 and GABABR2 during rat neocortical development. European Journal of Neuroscience 15(11):1766-78.

    http://www.ncbi.nlm.nih.gov/pubmed/12081656


    Wisden W, Cope D, Klausberger T, Hauer B, Sinkkonen ST, Tretter V, Lujan R, Jones A, Korpi ER, Mody I, Sieghart W, Somogyi P (2002) Ectopic expression of the GABA(A) receptor alpha6 subunit in hippocampal pyramidal neurons produces extrasynaptic receptors and an increased tonic inhibition. Neuropharmacology 43(4):530-49.

    http://www.ncbi.nlm.nih.gov/pubmed/12367600

  • Martínez-Galán JR, López-Bendito G, Luján R, Shigemoto R, Fairén A, Valdeolmillos M (2001) Cajal-Retzius cells in early postnatal mouse cortex selectively express functional metabotropic glutamate receptors. European Journal of Neuroscience 13(6):1147-54.
    http://www.ncbi.nlm.nih.gov/pubmed/11285012


    Luján R, Ciruela F (2001) Immunocytochemical localization of metabotropic glutamate receptor type 1 alpha and tubulin in rat brain. NeuroReport 12(6):1285-91.

    http://www.ncbi.nlm.nih.gov/pubmed/11338208


    López-Bendito G, Shigemoto R, Luján R, Juiz JM (2001) Developmental changes in the localisation of the mGluR1alpha subtype of metabotropic glutamate receptors in Purkinje cells. Neuroscience 105(2):413-29.

    http://www.ncbi.nlm.nih.gov/pubmed/11672608

  • Juiz JM, Luján R, Domínguez del Toro E, Fuentes V, Ballesta JJ, Criado M (2000) Subcellular compartmentalization of a potassium channel (Kv1.4): preferential distribution in dendrites and dendritic spines of neurons in the dorsal cochlear nucleus. European Journal of Neuroscience 12(12):4345-56.
    http://www.ncbi.nlm.nih.gov/pubmed/11122345

  • Soria JM, Martínez-Galán JR, Luján R, Valdeolmillos M, Fairén A (1999) Functional NMDA and GABAA receptors in pioneer neurons of the cortical marginal zone. European Journal of Neuroscience 11(9):3351-4.
    http://www.ncbi.nlm.nih.gov/pubmed/10510201

  • Somogyi P, Tamás G, Lujan R, Buhl EH (1998) Salient features of synaptic organisation in the cerebral cortex. Brain Research Reviews 26(2-3):113-35.
    http://www.ncbi.nlm.nih.gov/pubmed/9651498


    Reyes A, Lujan R, Rozov A, Burnashev N, Somogyi P, Sakmann B (1998) Target-cell-specific facilitation and depression in neocortical circuits. Nature Neuroscience 1(4):279-85.

    http://www.ncbi.nlm.nih.gov/pubmed/10195160


    Nusser Z, Lujan R, Laube G, Roberts JD, Molnar E, Somogyi P (1998) Cell type and pathway dependence of synaptic AMPA receptor number and variability in the hippocampus. Neuron 21(3):545-59.

    http://www.ncbi.nlm.nih.gov/pubmed/9768841

  • Luján R, Roberts JD, Shigemoto R, Ohishi H, Somogyi P (1997) Differential plasma membrane distribution of metabotropic glutamate receptors mGluR1 alpha, mGluR2 and mGluR5, relative to neurotransmitter release sites. Journal of Chemical Neuroanatomy 13(4):219-41.
    http://www.ncbi.nlm.nih.gov/pubmed/9412905

  • Luján R, Nusser Z, Roberts JD, Shigemoto R, Somogyi P (1996) Perisynaptic location of metabotropic glutamate receptors mGluR1 and mGluR5 on dendrites and dendritic spines in the rat hippocampus. European Journal of Neuroscience 8(7):1488-500.
    http://www.ncbi.nlm.nih.gov/pubmed/8758956

  • Carmona R, Luján R, Calvente R, Abadía-Molina F, Abadía-Fenoll F (1994) Quantitative alterations after long-term alcohol administration in the dorsal lateral geniculate nucleus (dLGN) in the rabbit (Oryctolagus cuniculus). Alcohol and Alcoholism 29(1):79-89.
    http://www.ncbi.nlm.nih.gov/pubmed/8003121


    Morilak, DA, Somogyi, P, Luján, R and Ciaranello, RD (1994) Neurons expressing 5-HT2 receptors in the rat brain: Neurochemical identification of cell types by immunocytochemistry. Neuropsychopharmacology 11:157-66.

    http://www.ncbi.nlm.nih.gov/pubmed/7865097